Pharmacokinetics of sulphadimi­dine in carp (Cyprinus carpio L.) and rainbow trout (Salmo gairdneri Richardson) acclimated at two different temperatu­res.

The influence of temperature(10 C° and 20 C°) on pharmacokinetics and metabolism of sulphadimidine(SDM) in carp and trout was studies. At 20 C° a significant lower level of distribution(VD_area) and a significantly shorter elimination half-life(T(½)β) was achieved in both species compared to the 10 C° level.In carp the body clearance parameter was significantly higher at 20 C° compared to the value at 10C°, whereas for  trout this parameters was in the same order of magnitude for both temperatures.

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